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Chandos Street runs northward from Cavendish Square and was named after James Brydges, 1st Duke of Chandos, who had agreed to build in Cavendish Square when plans were drawn up in 1719 by the Harley estate's surveyor John Prince. Prince's layout called for two avenues running north from the square: Harley Street to the west and Chandos Street to the east. The street therefore has direct origins in the founding geometry of the Cavendish-Harley Estate.
Chandos Street's most significant address is Chandos House, now at No. 2 Queen Anne Street at the head of the street. This Grade I listed building was designed by Robert Adam and built between 1769 and 1771 as a speculative venture by the Adam brothers on land belonging to the Duke of Portland's estate. In 1774 the lease was purchased by James Brydges, 3rd Duke of Chandos. The house later served as the Austrian Embassy from 1815, with Prince Esterházy as the first resident ambassador. It is now used as a venue by the Royal Society of Medicine.
At No. 11 Chandos Street sits Lettsom House, the home of the Medical Society of London, founded in 1773 by physician Dr John Coakley Lettsom. The building is named in his honour. This medical heritage places Chandos Street firmly within the broader Harley Street district, where professional medical life has concentrated for over two centuries. Harley Street lies a short distance to the west.
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