Old Marylebone Road runs roughly parallel to, and immediately south of, Marylebone Road in the NW1 postal district, forming part of the western section of the A501 corridor. The street is approximately 382 metres in length and is publicly maintained by Transport for London, reflecting its function as part of a major arterial route rather than a purely local street.
The name preserves the memory of an earlier alignment of the route that would become Marylebone Road. When the New Road was constructed in 1756 under Parliamentary authority, it established a new bypass north of the built-up area. Old Marylebone Road represents the surviving fragment of an older western access into the neighbourhood, predating the formal road-building of the mid-eighteenth century.
The area around Old Marylebone Road sits on the boundary between Marylebone proper and the Lisson Grove district to the north-west, an area with its own distinct working-class history shaped by the arrival of the Regent's Canal in 1810 and the railway at Marylebone in 1899. A listed building at 207 Old Marylebone Road is identified within the Bryanston and Dorset Square ward, which falls within the Portman Estate's western holdings. The road carries through traffic efficiently while the streets to its immediate south return quickly to residential scale. For context on the main arterial route, Marylebone Road runs the full east-west span of the neighbourhood's northern edge.
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