Weymouth Street runs east to west across central Marylebone, connecting Marylebone High Street to Great Portland Street. It was first laid out and built up in the late 1770s and early 1780s, as part of the same development push that produced Harley Street and Portland Place. The land was developed under the direction of the Harley family and passed, through marriage, into the Portland line before eventually becoming part of the Howard de Walden Estate, which today controls almost the entire street.
The western portion of the street was originally known as Bowling Green Lane, occupying ground that had formed part of the bowling green attached to the old Marylebone Gardens. That recreational past has long been absorbed into the fabric of a professional neighbourhood. The street lies within the Harley Street Conservation Area, and several Georgian terraced properties at numbers 45 to 49 survive from the original construction period. Two corner buildings carry Grade II* listing.
During the Second World War the street was struck twice by high explosive bombs. Rebuilding and incremental modernisation altered portions of the streetscape, though the general scale and grain of the Georgian layout remain legible. Today Weymouth Street functions primarily as a medical and professional address, in keeping with the wider district. The Weymouth Street Hospital, operated by Phoenix Hospital Group, opened following a complete rebuild in 2010. The street sits firmly within W1G, a short walk from Regent's Park to the north.
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